SAMETH, FITRIANI (2024) PENGARUH EKSTRAK ETANOL DAGING BUAH PALA (Myristica fragrans H.) PADA HISTOPATOLOGI GINJAL TERHADAP TIKUS WISTAR HIPERGLIKEMIK. Sarjana thesis, Universitas Khairun.

	Text Halaman Sampul.pdf - Published Version Download (26kB)
	Text ABSTRACT.pdf - Published Version Download (185kB)
	Text BAB I Pendahuluan.pdf - Published Version Download (203kB)
	Text DAFTAR PUSTAKA.pdf - Published Version Download (248kB)

Abstract

ABSTRACT Background: Diabetes is an important public health problem, and the prevalence of diabetes has continued to increase over the last few decades. DM can cause various complications and failure of various organs, one of which is the kidneys. This condition causes a decrease in blood flow and blood supply to the kidneys, which can result in disruption of the glomerular filtration process and impaired kidney function. Aim: to examine the effect of nutmeg pulp extract on the histopathology of hyperglycemic Wistar rat (Rattus novergicus) kidneys. Method: This research was designed as an experimental study. Using samples of 70% ethanol extract of nutmeg pulp (EDBP) on 25 male Wistar white male rats (Rattus novergicus) which were divided into 5 groups, namely negative control, metformin, EDBP 100 mg/KgBW, EDBP 200 mg/KgBW and EDBP 300 mg /KgBB. The test animals were induced on a high-carbohydrate diet for 7 days and continued with the administration of each test substance for 1 week, then observed changes in body weight, blood sugar levels, kidney organ weight and histopathology of the rat kidney organs in the glomeruli and kidney tubules. Data processing was then analyzed using the One Way ANOVA test. Results: All treatment groups given nutmeg pulp extract (EDBP) showed histopathological improvement in rat kidney glomeruli which was significantly different from the negative control group (p<0.05). Meanwhile, in rat kidney tubules, the extracts from the EDBP 100 mg and EDBP 200 mg groups showed no significant difference from the metformin group (p>0.05), while the EDBP 300 mg group showed a significant difference from the metformin group (p<0.05). Conclusion: Administration of ethanol extract of nutmeg flesh can improve the histopathological damage to the kidneys of hyperglycemic Wistar rats with an effective dose of 100 mg/KgBB and 200 mg/KgBB Keywords: Nutmeg Pulp, Ethanol Extract, Hyperglycemic, Kidney Histopathology, Myristica fragrans Houtt

Item Type:	Thesis (Sarjana)
Subjects:	R Medicine > R Medicine (General)
Divisions:	> Farmasih > Farmasih > Farmasih > Farmasih Fakultas > Farmasih Fakultas > Farmasih Fakultas > Farmasih
Depositing User:	Unnamed user with username yurni
Date Deposited:	29 Jul 2026 07:18
Last Modified:	29 Jul 2026 07:18
URI:	http://digilib.unkhair.ac.id/id/eprint/6692

Actions (login required)

View Item