CHANDRA, SERUNI (2024) AKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK ETANOL DAGING BUAH PALA (Myristica fragrans Houtt) TERHADAP TIKUS PUTIH (Rattus norvegicus). Sarjana thesis, Universitas Khairun.

	Text 1. COVER.pdf Download (297kB)
	Text 3. ABSTRAK.pdf Download (363kB)
	Text 5. BAB I.pdf Download (363kB)
	Text 12. DAFTAR PUSTAKA.pdf Download (419kB)

Abstract

ABSTRACT Background: Nutmeg (Myristica fragrans Houtt.) is rich in several bioactive phytochemical components including vitamins, carotenoids, terpenoids, alkaloids, flavonoids, lignin, simple phenols and phenolic acids. Ethanol extract of nutmeg flesh and leaves contains chemicals determined by phytochemical tests, especially alkaloids, flavonoids, tannins, terpenoids and saponins. Nutmeg flesh extract contains many flavonoids and terpenoids. Flavonoids have antioxidant properties, thanks to which they can fight the increase in reactive oxygen species (ROS) caused by diabetes. In addition, they have the ability to restore pancreatic β-cells and thus overcome insulin deficiency. Objective: The aim of this study was to evaluate the hypoglycemic properties of nutmeg flesh extract in white rats. Method: The animals used for the experiment were initially adapted to the conditions for 7 days. A total of 25 white rats (Rattus norvegicus) were divided into 5 treatment groups for the experiment. There were 5 white rats in each group. In the experiment, negative control (Na-CMC), positive control (metformin) and three different doses of extract were administered: Group I (100 mg/kg BW), Group II (200 mg/kg BW) and Group. III (300 mg/kg body weight). Dose was administered daily for 7 days. In the past, blood glucose levels were assessed both before fasting and after induction. The blood glucose level of the white rats was determined with a glucometer manufactured by the brand Accucheck®. Results: The statistical tests indicate that the Extract of Nutmeg Flesh (EDBP) group exhibits a noteworthy antihyperglycemic impact P=0,021 (P<0,05) at a dosage of 100 mg/kgBW. This effect is comparable to the positive control (Metformin) in terms of decreasing blood sugar levels. Conclusion: Extract of Nutmeg Flesh (EDBP) group exhibits a noteworthy antihyperglycemic impact P=0,021 (P<0,05) at a dosage of 100 mg/kgBW. This effect is comparable to the positive control (Metformin) in terms of decreasing blood sugar levels. Keywords: Antihyperglycemia, Flavonoids, Nutmeg Flesh, Extract, White Rat

Item Type:	Thesis (Sarjana)
Subjects:	R Medicine > R Medicine (General)
Divisions:	> Farmasih > Farmasih > Farmasih > Farmasih Fakultas > Farmasih Fakultas > Farmasih Fakultas > Farmasih
Depositing User:	Unnamed user with username yurni
Date Deposited:	06 Aug 2026 04:47
Last Modified:	06 Aug 2026 04:47
URI:	http://digilib.unkhair.ac.id/id/eprint/6762

Actions (login required)

View Item