LAHER, MULIANI (2024) UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BUNGA CENGKEH (Eugenia aromatica) TERHADAP BAKTERI Escherichia coli DARI SAMPEL KLINIS DI RSUD Dr. H. CHASAN BOESOIRIE TERNATE. Sarjana thesis, Universitas Khairun.

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Abstract

ABSTRAK Latar belakang: Infeksi merupakan masalah kesehatan terbesar tidak hanya di indonesia tetapi di dunia. Penyebab penyakit menular ini adalah bakteri E coli. Bakteri E coli mempunyai efek samping negatif yaitu dapat menimbulkan berbagai penyakit menular, dan antibiotik masih digunakan untuk mengatasi infeksi yang disebabkan oleh E coli. Penggunaan antibiotik dalam jangka panjang meningkatkan timbulnya resistensi, sehingga obat antimikroba dikembangkan dari bahan alami yang memiliki aktivitas antimikroba seperti cengkeh. Tujuan: untuk mengetahui ekstrak bunga cengkeh (Eugenia Aromatica) memiliki aktivitas antibakteri terhadap bakteri E coli dari sampel klinis di RSUD Dr. H. Chasan Boesoirie Ternate. Metode: Metode digunakan yaitu difusi sumuran yang menggunakan konsentrasi ekstrak bunga cengkeh uji 10%, 20%, 40%, 60%, 80% dan kontrol positif yaitu amoksisilin, kontrol negatif yaitu aqua pro injeksi. Hasil: Dari lima konsentrasi ekstrak terdapat hasil bahwa ekstrak etanol bunga cengkeh (Eugenia Aromatica) memiliki aktivitas antibakteri dengan melihat zona hambat yang terbentuk. Konsentrasi ekstrak 80% merupakan yang paling efektif dalam menghambat pertumbuhan E coli, dengan rerata zona hambat sebesar 18,63 mm, yang tergolong kuat. Kesimpulan : Ekstrak etanol bunga cengkeh (Eugenia aromatika) mempunyai efek antibakteri terhadap pertumbuhan E coli, semakin tinggi konsentrasi ekstrak maka semakin besar zona hambat yang terbentuk. Kata kunci: E coli, Bunga cengkeh, Antibakteri, sampel klinis ANTIBACTERIAL ACTIVITY TEST OF ETHANOL EXTRACT OF CLOVE FLOWERS (Eugenia aromatica) AGAINST Escherichia coli FROM CLINICAL SAMPLES AT DR. H. CHASAN BOESOIRIE REGIONAL GENERAL HOSPITAL, TERNATE Muliani Laher, Ismail Rahman, Muhammad Subhan A. Sibadu, Department of Pharmacy, Faculty of Medicine, Khairun University ABSTRACT Introduction: Infection is a major health concern globally, including in Indonesia. A common culprit of these infections is E. coli bacteria, which can lead to a range of illnesses. While antibiotics are commonly used to treat E. coli infections, their prolonged use can lead to antibiotic resistance. To address this issue, there is growing interest in developing antimicrobial drugs from natural sources, such as cloves, which possess inherent antimicrobial properties. Aim: To evaluate the antibacterial activity of clove flower extract (Eugenia aromatica) against E. coli bacteria isolated from clinical samples at Dr. H. Chasan Boesoirie Ternate Regional Hospital. Methods: The method employed was the well diffusion assay, using clove flower extract concentrations of 10%, 20%, 40%, 60%, and 80%. The positive control was amoxicillin, while the negative control was sterile water. Result: Among the five concentrations of clove flower extract tested, the ethanol extract of Eugenia aromatica demonstrated antibacterial activity, as indicated by the formation of inhibition zones. The 80% extract concentration was the most effective, with an average inhibition zone of 18.63 mm, classified as strong inhibition against E. coli. Conclusion: Ethanol extract of clove flowers (Eugenia aromatica) has an antibacterial effect on the growth of E. coli, the higher the concentration of the extract, the larger the inhibition zone formed. Keywords: E coli, Clove flower, Antibacterial, Clinical Sample

Item Type:	Thesis (Sarjana)
Subjects:	R Medicine > R Medicine (General)
Divisions:	> Farmasih > Farmasih > Farmasih > Farmasih Fakultas > Farmasih Fakultas > Farmasih Fakultas > Farmasih
Depositing User:	Unnamed user with username yurni
Date Deposited:	31 Jul 2026 08:21
Last Modified:	31 Jul 2026 08:21
URI:	http://digilib.unkhair.ac.id/id/eprint/6714

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